253785-51-2Relevant academic research and scientific papers
Synthesis and evaluation of a new fluorine-18 labeled rotenoid as a potential pet probe of mitochondrial complex I activity
Martarello, Laurent,Greenamyre, J. Timothy,Goodman, Mark M.
, p. 1039 - 1051 (1999)
Fluorine-18 labeled (6aS, 12aS, 5'R)-12-deoxo-6',7'-dihydro-7'-fluororotenone (F-DDRT), a new potential PET probe of mitochondrial complex I activity, was synthesized. [18F]-DDRT was prepared with good specific activity by nucleophilic displacement with an overall radiochemical yield of 25% (EOB). The uptake of [18F]-DDRT in rat brain and heart was compared with the uptake of another fluorine-18 labeled rotenoid: [18F]-DHRT. In comparison to [18F]-DHRT, the brain and heart retention of [18F]-DDRT were both lower at any point of the study (respectively 0.49 and 2.82% dose/g vs 0.34 and 1.24% dose/g at 60 min post injection).
