253867-08-2

Upstream product

• 141580-65-6 N,O-Bis(phenoxycarbonyl)hydroxylamine 
• 253867-07-1 (2S,6S)-6-(4-Fluorophenoxymethyl)-2-(1-hydroxybut-3-yn-4-yl)tetrahydropyran 
• 1972-28-7 diethylazodicarboxylate 
• 278170-41-5 (2RS,6S)-2-(Benzenesulfonyl)-6-(4-fluorophenoxymethyl)tetrahydropyran 
• 278170-39-1 (2S)-2-(1-Ethenoxy)-1-(4-fluorophenoxy)hex-5-ene 
• 278170-38-0 (2S)-1-(4-Fluorophenoxy)hex-5-en-2-ol 
• 278170-40-4 (2S)-2-(4-Fluorophenoxymethyl)-3,4-dihydro-2H-pyran 
• 104605-98-3 (2S)-2-[(4-fluorophenoxy)methyl]oxirane 

Relevant academic research and scientific papers

Substituted oxygen alicyclic compounds, including methods for synthesis thereof

The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

A versatile approach to anti-asthmatic compound CMI-977 and its six- membered analogue

The synthesis of the anti-asthmatic compound CMI-977 is described. The tetrahydrofuran ring was effectively constructed by involving olefin metathesis while the stereoselective introduction of the 1-N- hydroxyureidylbut-3-yn-4-yl side-chain was achieved b