2539-22-2

Basic information

• Product Name: vanillin
• Synonyms: vanillin
• CAS NO: 2539-22-2
• Molecular Weight: 196.246
• Mol File: 2539-22-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: vanillin(CAS DataBase Reference)
• NIST Chemistry Reference: vanillin(2539-22-2)
• EPA Substance Registry System: vanillin(2539-22-2)

Safety Data

• Hazardous Substances Data: 2539-22-2(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 2538-98-9 4-isopropyloxy-3-methoxybenzaldehyde 

Downstream Products

• 861069-45-6 vanillin 
• 88449-50-7 2-(4-isopropoxy-3-methoxyphenyl)acetic acid 

Relevant articles and documents

Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents

Enlightened by the modification route from Camptothecin (CPT) to Topotecan and based on classical drug design theory, a series of Mannich derivatives of lamellarin D were designed and synthesized in 26-27 steps starting from vanillin and isovanilin. All synthesized compounds were then biologically evaluated for their in vitro anti-cancer activities and Topo I inhibitory activities. The results showed that most target compounds exhibited Topo I inhibitory activities in equivalent level with that of lamellarin D. Compound SL-9 exhibited better Topo I inhibitory activity than that of lamellarin D. Compounds SL-2, SL-3, SL-4, SL-5 and SL-11 exhibited better anti-proliferative activity against HT-29 cells than that of lamellarin D.