25395-13-5

Basic information

• Product Name: 5-chloroquinolin-8-ol hydrochloride
• Synonyms: 5-chloroquinolin-8-ol hydrochloride;5-Chloro-8-Hydroxyquinoline Hydrochloride;5-CHLORO-8-HYDROXYQUINOLINEHCL;cloxyquin hydrochloride;8-Quinolinol, 5-chloro-, hydrochloride(1:1)
• CAS NO: 25395-13-5
• Molecular Formula: C₉H₆ClNO*ClH
• Molecular Weight: 216.06398
• EINECS: 246-939-1
• Mol File: 25395-13-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 348.7°C at 760 mmHg
• Flash Point: 164.7°C
• Appearance: /
• Vapor Pressure: 2.46E-05mmHg at 25°C
• CAS DataBase Reference: 5-chloroquinolin-8-ol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloroquinolin-8-ol hydrochloride(25395-13-5)
• EPA Substance Registry System: 5-chloroquinolin-8-ol hydrochloride(25395-13-5)

Safety Data

• Hazardous Substances Data: 25395-13-5(Hazardous Substances Data)

Usage

General Description

5-chloroquinolin-8-ol hydrochloride is a chemical compound that consists of a quinoline ring with a chloro group and a hydroxyl group attached to it. The hydrochloride salt form of this compound is commonly used in the pharmaceutical industry as an active pharmaceutical ingredient in the synthesis of various drugs. It has been studied for its potential anti-inflammatory, antiviral, and antimicrobial properties. Additionally, 5-chloroquinolin-8-ol hydrochloride has potential applications in the development of novel therapeutics for a range of medical conditions. As a result, it is an important compound in pharmaceutical research and development.

InChI:InChI=1/C9H6ClNO.ClH/c10-7-3-4-8(12)9-6(7)2-1-5-11-9;/h1-5,12H;1H

Upstream product

• 89-64-5 p-chloro-o-nitrophenol 
• 56-81-5 glycerol 
• 95-85-2 2-hydroxy-5-chloro-aniline 

Relevant articles and documents

Preparation method of 5-chloro-8-hydroxyquinoline and purification method thereof

The invention discloses a preparation method of 5-chloro-8-hydroxyquinoline and a purification method thereof, which aims at solving the problem when 4-chloro-2-aminophenol, 4-chloro-2-nitrophenol andglycerol ring are used to obtain 5-chloro-8-hydroxyquinoline, the reaction process is difficult to control, so that a large amount of tar can be generated, the reaction yield is low, the reaction operation is difficult, and a large amount of waste acid is generated after the post treatment. Boric acid and insoluble organic solvents being added into the reaction solution is the innovation of the preparation method, by the method, the acuteness of direct production of acrolein from sulphuric acid and glycerol is mitigated by boric acid, the speed of the acrolein polymerization to generate the tar is reduced, the yield and the safety are effectively improved, and a small amount of an water-insoluble organic solvents can effectively prevent 4-chloro-2-nitrophenol from coagulating on the reactor wall, the problem that it is difficult to control in the process of production operation is solved, which shortens the reaction cycle and improves production efficiency. The preparation method of 5-chloro-8-hydroxyquinoline and purification method thereof has the advantages of less tar, high yield and safe reaction, and can effectively reduce waste acid production and is easy to industrialize.