254-37-5

Upstream product

• 108-98-5 thiophenol 
• 504-63-2 trimethyleneglycol 
• 1174229-14-1 (2-bromophenyl)(cyclopropyl)sulfane 
• 6320-02-1 o-bromothiophenol 
• 40316-60-7 thiochroman-4-ol 

Downstream Products

• 1075-14-5 2H-thiochromen-2-one 
• 17698-40-7 (3S,4R)-3,4-chromanediol 
• 1195-14-8 2-Methylbenzothiophene 

Relevant academic research and scientific papers

Cyclopropyl Thioethers, New Inputs for Palladium Catalyzed Ring Opening of Cyclopropanes

We present herein a new palladium-catalyzed ring opening of cyclopropane-substituted thioethers. The study involves an intramolecular trapping of an intermediate aryl palladium to afford thiochromene derivatives. In contrast to the analogous cyclopropylam

Direct Access to S-Heterocycles by Scandium(III) Triflate Catalyzed Cyclization of Aromatic Thiols and Diols

A simple and environmentally friendly method to prepare S-heterocycles by cyclization of aromatic thiols and diols with H2O as a byproduct is described. The Sc(OTf)3-catalyzed dehydrative cyclizations of aromatic thiols and diols provided the corresponding thiopyran and thiophene derivatives. Control experiments were also performed to obtain insights into the reaction pathway.

NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from -S(=O)pRa, where Ra is -C1-C4 alkyl, -ORx, -NRxRx, -NHNRxRx, - NHNHC(=O)ORx, -NRxOH; -C(=O)-Rb, where Rb is -CT-C4-alkyl, ORx, -NRxRx, -NHNRxRx, -NHC1-C3-alkyl-C(=O)Orx -NRxRc, where Rc is H, C1-C4 alkyl, -NRxRx; -C(=0)Rd, -CN, S(=O)pRx where Rd is Rd is C1-C4-alkyl, -ORx, -NRxRx C1-C3-alkyl-O-Cl-C3alkylC(=O)ORx, -C1-C3-alkyl-COORx; -C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O-Cl-C3alkyl)q-O-Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, -S(=O),- or -CH2-, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is -(CR8R8')n-D-(CR8R8')m-; D is a bond, -NR9-, -0-, -S-, -S(=0)- or -S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.

A Study of 2-Propenethials Obtained by Flash Vacuum Pyrolysis of 2-Ethenyl-1,3-dithiolane 1,1-Dioxides

Synthesis of substituted 2-propenethials by the flash vacuum pyrolysis of appropriately substituted 2-ethenyl-1,3-dithiolane 1,1-dioxides has been investigated.Pyrolysis of 2-propenyl-1,3-dithiolane 1,1-dioxide (5a) gives thiophene, 2,5-dihydrothiophene, a dimer (11) and dimer (12) of 2-butenethial (4a).Pyrolysis of 2-(1-methylpropenyl)-1,3-dithiolane 1,1-dioxide (5b) gives 3-methylthiophene and a trimer (14) of 2-methyl-2-butenethial (4b).Pyrolysis of 2-(2-phenylethenyl)-1,3-dithiolane 1,1-dioxide (5c) gives 2H-1-benzothiin (15) and a dimer (16) of 3-phenyl-2-propenethial (4c).The dimer (11), 2-propenyl-4-methyl-4H-1,3-dithiin, can be considered as the meta-substituted cycloaddition product of 2-butenethial, whereas the dimer (16), 3-(2-phenylethenyl)-4-phenyl-3,4-dihydro-1,2-dithiin, can be considered as the ortho-substituted cycloaddition product of 2-phenyl-2-propenethial.