25403-35-4

Upstream product

• 501-65-5 diphenyl acetylene 
• 110-91-8 morpholine 
• 52711-23-6 3-(methylthio)-2-phenyl-1H-inden-1-one 
• 94744-39-5 1-oxo-2-phenyl-1H-indene-3-carbonitrile 
• 536-74-3 phenylacetylene 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 

Relevant academic research and scientific papers

MeOTf-Induced Carboannulation of Isothiocyanates and Aryl Alkynes with C=S Bond Cleavage: Access to Indenones

MeOTf-induced carboannulation of alkyl isothiocyanates and aryl alkynes for the synthesis of indenones in good yields under metal-free conditions with C=S bond cleavage is described. The thioalkoxy group at the 3-position of the indenone can also be converted into other functional groups, such as phenyl, methylsulfonyl, amino, and ethoxy groups.

Palladium(ii)-catalyzed synthesis of functionalized indenones via oxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles

A one-pot two-step synthesis of versatile indenones has been developed. This palladium(ii)-catalyzed transformation involves generation and condensation of ortho-functionalized 1,2-benzils from 2-(2-arylethynylphenyl)acetonitriles using Ph2SO as the oxidant. The resulting 3-cyanoindenones can be converted to various valuable molecules.