25407-10-7Relevant academic research and scientific papers
Efficient nucleophilic aromatic substitution between aryl nitrofluorides and alkynes
DeRoy, Patrick L.,Surprenant, Simon,Bertrand-Laperle, Megan,Yoakim, Christiane
, p. 2741 - 2743 (2007)
Equation Presented The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mild conditions.
One-Pot Synthesis of Indole Derivatives from the Reaction of Nitroalkynes and Alkynes via a Mercury-Carbene Intermediate
Zheng, Min,Chen, Kai,Zhu, Shifa
, p. 4173 - 4182 (2017/09/13)
The cyclization of nitroalkyne catalyzed by Hg(OTf) 2 to produce the corresponding benzo[ c ]isoxazole in excellent yields with high selectivity is reported. On the basis of this strategy, a one-pot method to synthesize indole derivatives has been developed. In this transformation, two Hg-carbene intermediates are proposed to be involved..
