254107-74-9Relevant academic research and scientific papers
Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Dinsmore, Christopher J.,Zartman, C. Blair,Bergman, Jeffrey M.,Abrams, Marc T.,Buser, Carolyn A.,Culberson, J. Christopher,Davide, Joseph P.,Ellis-Hutchings, Michelle,Fernandes, Christine,Graham, Samuel L.,Hartman, George D.,Huber, Hans E.,Lobell, Robert B.,Mosser, Scott D.,Robinson, Ronald G.,Williams, Theresa M.
, p. 639 - 643 (2007/10/03)
A series of macrocyclic piperazinone compounds with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to be potent inhibitors of protein prenylation in cell culture. A hypothesis for the binding mode of compound 3o in FPTase is proposed.
