254108-59-3Relevant academic research and scientific papers
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Bergman, Jeffrey M,Abrams, Marc T,Davide, Joseph P,Greenberg, Ian B,Robinson, Ronald G,Buser, Carolyn A,Huber, Hans E,Koblan, Kenneth S,Kohl, Nancy E,Lobell, Robert B,Graham, Samuel L,Hartman, George D,Williams, Theresa M,Dinsmore, Christopher J
, p. 1411 - 1415 (2007/10/03)
A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibition of
