2544-12-9

Usage

Uses

Used in Pharmaceutical Industry:
rac α-AMino-3,4-diMethoxy-α-Methylbenzenepropanenitrile Hydrochloride is used as an intermediate in the synthesis of α-Methyl DOPA (M303800), an antihypertensive agent. Its unique chemical structure allows for the development of this medication, which is effective in treating high blood pressure and related cardiovascular conditions.
The compound's role as an intermediate in the production of α-Methyl DOPA highlights its importance in the pharmaceutical industry, as it contributes to the development of life-saving medications for hypertension management. Its specific chemical properties enable the creation of a drug that can effectively regulate blood pressure, improving the quality of life for patients suffering from this condition.

Upstream product

• 2543-46-6 (±)-3-(3,4-dimethoxyphenyl)-2-amino-2-methylpropanenitrile 

Relevant academic research and scientific papers

L - 3 - (3, 4 - dimethoxyphenyl) -2 - amino -2 - methyl propionitrile hydrochloride preparation method

The invention relates to the technical field of medical chemistry and aims at providing a method for preparing L-3-(3,4-dimethoxyphenyl)-2-amino-2-methyl propionitrile hydrochloride. The method comprises the following steps: adding veratone, sodium cyanide, ammonium chloride and ammonia water into a reaction kettle, and introducing ammonia gas; cooling and performing centrifugal separation after the reaction is ended, thereby obtaining D,L-aminopropionitrile; dissolving the D,L-aminopropionitrile in an organic solvent, adding L(+)-2,3-dihydrobutanedioic acid, stirring and reacting; adding hydrochloric acid for stirring, and cooling for performing centrifugal separation treatment, thereby obtaining the L-3-(3,4-dimethoxyphenyl)-2-amino-2-methyl propionitrile hydrochloride. According to the method disclosed by the invention, the conversion rate of veratone is high and can be 90-95 percent. The ammonia water mother solution and organic solvent produced in the reaction can be recycled and are repeatedly used for many times, and the environmental pollution is reduced. The solvent used in the reaction replaces water, and sewage emission is completely reduced. The amount of a resolving agent can be reduced by a half, and the resolving effect is good; complex operations such as regulation of the pH value and the like are not needed, and the preparation process is stable and easy to operate.