25443-91-8

Upstream product

• 671212-34-3 [2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 2759-28-6 1-phenylmethylpiperazine 
• 103-80-0 phenylacetyl chloride 
• 361979-30-8 2-amino-1-(4-benzylpiperazin-1-yl)ethan-1-one 

Relevant academic research and scientific papers

Inhibition of Ebola virus infection: Identification of niemann-pick C1 as the target by optimization of a chemical probe

A high-throughput screen identified adamantane dipeptide 1 as an inhibitor of Ebola virus (EboV) infection. Hit-to-lead optimization to determine the structure-activity relationship (SAR) identified the more potent EboV inhibitor 2 and a photoaffinity labeling agent 3. These antiviral compounds were employed to identify the target as Niemann-Pick C1 (NPC1), a host protein that binds the EboV glycoprotein and is essential for infection. These studies establish NPC1 as a promising target for antiviral therapy.