25458-46-2

Basic information

• Product Name: Benzene, 1-methoxy-4-(methoxymethoxy)-
• CAS NO: 25458-46-2
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Mol File: 25458-46-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-(methoxymethoxy)-(25458-46-2)
• EPA Substance Registry System: Benzene, 1-methoxy-4-(methoxymethoxy)-(25458-46-2)

Safety Data

• Hazardous Substances Data: 25458-46-2(Hazardous Substances Data)

Upstream product

• 13057-17-5 bromethyl methyl ether 
• 1200-06-2 4-methoxyphenyl acetate 
• 109-87-5 Dimethoxymethane 
• 105-13-5 4-Methoxybenzyl alcohol 
• 150-76-5 4-methoxy-phenol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 141362-11-0 9-<5-methoxy-2-(methoxymethoxy)phenyl>phenanthrene 
• 156416-89-6 1-<2-(methoxymethyloxy)-5-methoxyphenyl>-3,7-dimethyl-2,6-octadien-1-ol 
• 127136-79-2 2-Methoxymethoxy-5-methoxytoluene 
• 127136-76-9 C₁₂H₂₁N₂O₃P 
• 172980-32-4 1,2-Dimethoxy-8-<5-methoxy-2-(methoxymethoxy)phenyl>phenanthrene 
• 127285-27-2 5-Methoxy-2-methoxymethoxyaniline 
• 226565-84-0 (5-Methoxy-2-methoxymethoxy-phenyl)-((2R,3S)-3-propyl-oxiranyl)-methanone 
• 308365-72-2 (5-Methoxy-2-methoxymethoxy-phenyl)-[(2S,3R)-3-propyl-1-(toluene-4-sulfonyl)-aziridin-2-yl]-methanone 
• 307492-77-9 4-methoxy-1-(methoxymethoxy)-2-(3-methylbut-2-en-1-yl)benzene 
• 658707-40-5 2-(dicyclohexylphosphanyl)-4-methoxyphenyl methoxymethyl ether 
• 877128-16-0 2-[bis(dimethylamino)phosphino]-4-methoxyphenyl-methoxymethylether 
• 73220-20-9 5-methoxy-2-(methoxymethoxy)benzaldehyde 
• 877128-19-3 2-(dimethylaminophenylphosphino)-4-methoxyphenyl-methoxymethylether 
• 851182-68-8 2-(bromomethyl)-4-methoxy-1-(methoxymethoxy)benzene 

Relevant articles and documents

Platinum-catalyzed α,β-unsaturated carbene formation in the formal syntheses of frondosin B and liphagal

Formal syntheses of tetracyclic terpenoids frondosin B and liphagal are described. Both synthetic routes rely on the use of platinum-catalyzed α,β-unsaturated carbene formation for the key C-C bond forming transformations. The successful route toward frondosin B utilizes a formal (4 + 3) cycloaddition, while the liphagal synthesis features the vinylogous addition of an enol nucleophile as a key step. Both synthetic routes are discussed, revealing insights into structural requirements in the catalytic a,β-unsaturated carbene reaction manifold.

SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

The reaction of acetal-type protective groups in combination with TMSOTf and 2,2′-bipyridyl; Mild and chemoselective deprotection and direct conversion to other protective groups

A mild and chemoselective deprotection method of various acetal-type protective groups, such as MOM, MEM, BOM, and SEM ethers, has been developed. The combination of TMSOTf and 2,2′-bipyridyl was very effective for the deprotection, and the reaction proceeded via the formation of pyridinium intermediates, which were hydrolyzed to the corresponding alcohols in good to high yields. The features of this method are mild (almost neutral) reaction conditions and the tolerability of acid-sensitive functional groups. This method is also applicable for the direct conversion of MOM ether to BOM or SEM ether using the appropriate alcohols instead of H2O.