25458-48-4

Basic information

• Product Name: 1-MethoxyMethoxy-3-nitro-benzene
• Synonyms: 1-MethoxyMethoxy-3-nitro-benzene
• CAS NO: 25458-48-4
• Molecular Formula: C₈H₉NO₄
• Molecular Weight: 183.16136
• Mol File: 25458-48-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-MethoxyMethoxy-3-nitro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-MethoxyMethoxy-3-nitro-benzene(25458-48-4)
• EPA Substance Registry System: 1-MethoxyMethoxy-3-nitro-benzene(25458-48-4)

Safety Data

• Hazardous Substances Data: 25458-48-4(Hazardous Substances Data)

Upstream product

• 554-84-7 meta-nitrophenol 
• 107-30-2 chloromethyl methyl ether 

Relevant articles and documents

HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF

A compound represented by Formula I or pharmaceutically acceptable salt thereof. The present invention relates to a 4-arylamino quinazoline hydroxamic acid compound having a histone deacetylase inhibitory activity, preparation method of the compound, pharmaceutical composition comprising the compound, and use of the compound and the pharmaceutical composition in the preparation of a histone deacetylase inhibitor medicine. The present invention aims at acquiring, via a medicine design and a synthetic technology, a series of selective histone deacetylase inhibitors having good hypotype selectivity and favorable pharmacokinetic characteristics based on optimization of an enzyme surface recognition region and connection region of 4-arylamino quinazoline, thus reducing an effect on normal tissues or cells while improving an antineoplastic activity of the normal tissues or cells.

A histone deacetylase inhibitor and its preparation and use (by machine translation)

The invention provides a compound of formula I illustrated compound or its pharmaceutically acceptable salt, relates to has the histone deacetylase inhibitory activity of the 4 - aryl amino [...] novel class of compound, the preparation of the compounds, comprising the pharmaceutical composition and the compounds and pharmaceutical compositions in the preparation of histone deacetylase enzyme inhibitor drug in its class of use; aimed at through the drug design and synthesis means based on obtaining a series of 4 - aryl amino [...] surface of the cleat and linkage area optimization, with subtype selective and good medicine generation of dynamics characteristic of selective histone deacetylase inhibitors, in order to improve the anti-tumor activity at the same time to reduce the impact of the normal tissue or cells. (by machine translation)

ISO-CBI and ISO-CI analogs of CC-1065 and the duocarmycins

A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA bin