2546-52-3 Usage
Uses
Used in Organic Synthesis:
3-Fluoro-4-bromopyridine hydrochloride is used as a research reagent for organic synthesis, where it plays a crucial role in the development of new chemical compounds and reactions. Its unique structure and properties allow chemists to explore novel pathways and mechanisms in organic chemistry.
Used in Chemical Processes:
In the realm of chemical processes, 3-Fluoro-4-bromopyridine hydrochloride is utilized as a reagent to facilitate specific transformations and reactions. Its presence can enhance the efficiency and selectivity of certain processes, contributing to the advancement of chemical technology and industry.
Used in Pharmaceutical Development:
3-Fluoro-4-bromopyridine hydrochloride is also employed in the pharmaceutical industry as a building block for the synthesis of potential drug candidates. Its unique combination of fluorine and bromine atoms can impart specific biological activities and properties to the resulting compounds, making it a valuable asset in drug discovery and development.
Used in Material Science:
In the field of material science, 3-Fluoro-4-bromopyridine hydrochloride can be used as a component in the design and synthesis of new materials with tailored properties. Its incorporation into polymers, coatings, or other materials can lead to improved performance characteristics, such as enhanced stability, reactivity, or selectivity.
Overall, 3-Fluoro-4-bromopyridine hydrochloride is a versatile and valuable compound with a wide range of applications across various industries, including organic synthesis, chemical processes, pharmaceutical development, and material science. Its unique properties and reactivity make it an essential tool for researchers and scientists in their pursuit of new discoveries and innovations.
Check Digit Verification of cas no
The CAS Registry Mumber 2546-52-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,4 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2546-52:
(6*2)+(5*5)+(4*4)+(3*6)+(2*5)+(1*2)=83
83 % 10 = 3
So 2546-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrFN/c6-4-1-2-8-3-5(4)7/h1-3H
2546-52-3Relevant academic research and scientific papers
REVIEW ON THE METALLATION OF ?-DEFICIENT HETEROAROMATIC COMPOUNDS; REGIOSELECTIVE ORTHO-LITHIATION OF 3-FLUOROPYRIDINE: DIRECTING EFFECTS AND APPLICATION TO SYNTHESIS OF 2,3- OR 3,4-DISUBSTITUTED PYRIDINES
Marsais, Francis,Queguiner, Guy
, p. 2009 - 2021 (2007/10/02)
Metallation of ?-deficient heterocyclic compounds is first reviewed, which shows the important recent developments in this research area.A particular aspect of this reaction is then given with the study of the 3-fluoropyridine metallation regioselectivity.Lithiation of 3-fluoropyridine is chemoselective at low temperatures using butyllithium-polyamine chelates or lithium diisopropylamide.Protophilic attack by these strong bases can be directed either at the 2- or 4-position depending on the lithiation conditions.Various reaction parameters are thus studied such as solvent, temperature, reaction time, lithium-chelating agent as well as metallating agent.The high regioselectivity of 3-fluoropyridine lithiation is theoretically discused, in particular in terms of kinetic of thermodynamic control of the metallation.Chelation between butyllithium and 3-fluoropyridine is proposed, which completely modifies the heterocycle reactivity toward the lithiating agent.This is confirmed by theoretical quantum calculations performed on different models of 3-fluoropyridine using the CNDO/2.These results allow to select the best 3-fluoropyridine-metallation conditions which lead to 3-fluoro-2-lithiopyridine on the one hand and to 3-fluoro-4-lithiopyridine on the other hand.Each of the lithiated isomers is then reacted with a great variety of electrophiles which gives very conveniently the corresponding 2,3- or 3,4-disubstituted pyridines.
