25460-12-2Relevant articles and documents
Inhibition of squalene synthase of rat liver by abietane diterpenes derivatives
Macías-Alonso, Mariana,Andrés, Lucía S.,Córdova-Guerrero, Iván,Estolano-Cobián, Arturo,Díaz-Rubio, Laura,Marrero, Joaquín G.
, p. 2972 - 2976 (2021)
In the current study, chemical composition of cultivated Salvia canariensis L was determined. Carnosol was the main product isolated. We prepared more lipophilic derivatives from carnosol, and both isolated and semisynthetic abietane diterpenes were evaluated in?vitro as inhibitors of squalene synthase. Among the compounds tested, carnosol was the most potent inhibitor (IC50 = 17.6 μM). These results highlight the great potential of this species for the production of new ingredients in nutritional supplements for the treatment of hyperlipidemia.
Isolation, structure determination, and absolute configuration of barbatusol: A new bioactive diterpene with a rearranged abietane skeleton from the labiate Coleus barbatus
Kelecom
, p. 3603 - 3608 (1983)
Barbatusol, isolated from the Labiate Coleus barbatus Bentham, is shown to be a new phenolic diterpene with a rearranged abietane skeleton. Absolute configuration is established by hemisynthesis of barbatusol dimethyl-ether from the known carnosol. Barbatusol is endowed with biological activity.
Application of carnosol compounds in preparation of medicines for treating cachexia diseases
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Paragraph 0163, (2021/08/14)
The invention innovatively provides application of carnosol compounds in preparation of medicines for treating cachexia for the first time. The carnosol compound comprises a carnosol compound shown as a formula X, dimethyl deuterated carnosol shown as a formula 1, dimethyl carnosol shown as a formula 2 and the like. The invention further provides a novel compound, namely the dimethyl deuterated carnosol shown in the formula 1 and a preparation method thereof. The invention also provides pharmaceutical compositions for treating cachexia diseases. The invention further provides application of the carnosol compounds in preparation of the medicines for treating tumor cachexia, including amyotrophy caused by tumor tissue, adipopenia caused by the tumor tissue, appetite reduction caused by the tumor tissue, inflammatory response caused by the tumor tissue and tumor cachexia caused by digestive tract related cancers, liver cancer, lung cancer and colon cancer. The invention also provides the application in preparation of medicines or inhibitors for treating or inhibiting amyotrophy, drugs or inhibitors for inhibiting or relieving lipolysis of fat cells, and drugs or inhibitors for inhibiting or relieving weight loss or decrease. The carnosol compounds and medicines have a wide application prospect.
Oxidative C-ring opening of abietane diterpenes with ammonium cerium(IV) nitrate
Marrero, Joaquín González,San Andrés, Lucía,Luis, Javier Gutiérrez
, p. 1127 - 1129 (2008/03/11)
The oxidation reaction of 11,12-di-O-methylcarnosol with ammonium cerium(IV) nitrate (CAN) gave an abietane diterpene with the C-ring opened and a diester function. The structure of this diester was established by spectroscopic analysis and by chemical means. The reaction of 11,12-di-O-dimethylgaldosol with CAN gave a similar result, yielding a δ-lactone which structure was established as 7-hydroxy-11,12-seco-8,13- abietadien-12,7:20,6β-dilacton-11-oic acid methyl ester by spectroscopic analysis and chemical means. These results could be useful to accede to other natural products like rosmic acid Georg Thieme Verlag Stuttgart.
