254737-29-6Relevant articles and documents
Enantiospecificity of glutamate carboxypeptidase II inhibition
Tsukamoto, Takashi,Majer, Pavel,Vitharana, Dilrukshi,Ni, Chiyou,Hin, Bunda,Lu, Xi-Chun M.,Thomas, Ajit G.,Wozniak, Krystyna M.,Calvin, David C.,Wu, Ying,Slusher, Barbara S.,Scarpetti, David,Bonneville, George W.
, p. 2319 - 2324 (2005)
Two representative glutamate carboxypeptidase II (GCP II) inhibitors, 2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid 2 and 2-(3-mercaptopropyl)pentanedioic acid 3, were synthesized in high optical purities (>97%ee). The two enantiom
Naaladase inhibitors for treating retinal disorders and glaucoma
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, (2008/06/13)
The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
NAALADase inhibitors useful as pharmaceutical compounds and compositions
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, (2008/06/13)
The present invention relates to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neur