25474-90-2Relevant academic research and scientific papers
Ortho-Selective Hydrogen Isotope Exchange of Phenols and Benzyl Alcohols by Mesoionic Carbene-Iridium Catalyst
Zhao, Liang-Liang,Wu, Yixin,Huang, Shiqing,Zhang, Zengyu,Liu, Wei,Yan, Xiaoyu
supporting information, p. 9297 - 9302 (2021/11/30)
Hydrogen isotope exchange reactions of phenols and benzyl alcohols have been achieved by a mesoionic carbene-iridium catalyst with high ortho selectivity and high functional group tolerance. Control experiments indicated that acetate is crucial to realize the ortho selectivity, whereas density functional theory calculations supported an outer-sphere direction with hydrogen bonding between acetate and the hydroxyl group.
Shifted Selectivity in Protonation Enables the Mild Deuteration of Arenes through Catalytic Amounts of Bronsted Acids in Deuterated Methanol
Fischer, Oliver,Hubert, Anja,Heinrich, Markus R.
, p. 11856 - 11866 (2020/10/23)
Taking advantage of the "differentiating effect"of the solvent methanol, deuterations of electron-rich aromatic systems can be carried out under mild acid catalysis and thus under far milder conditions than known so far. The exceptional functional group t
A simple and cost-effective method for the regioselective deuteration of phenols
Zhan, Miao,Xu, Ruixue,Tian, Ye,Jiang, Hongxia,Zhao, Lifeng,Xie, Yongmei,Chen, Yuanwei
supporting information, p. 3370 - 3373 (2015/05/20)
A highly effective and operationally simple method for the deuteration of phenols using NaOH as a catalyst and D2O as the deuterium source is presented. A high regioselectivity for the ortho and/or para hydrogens relative to the oxygen atom was
