254761-52-9

Upstream product

• 254761-50-7 (2R,3R)-3-amino-1-(tert-butyldimethylsilyloxy)-3-(4-methoxyphenyl)-2-propanol 
• 105-58-8 Diethyl carbonate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 220736-25-4 (4R,5R)-cytoxazone 
• 254761-49-4 (2R,3R)-3-azido-1-(tert-butyldimethylsilyloxy)-3-(4-methoxyphenyl)-2-propanol 

Downstream Products

• 1613057-71-8 (4R,5R)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one 
• 1613057-72-9 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate 
• 1613057-73-0 ((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl benzoate 
• 220736-25-4 (4R,5R)-cytoxazone 

Relevant academic research and scientific papers

Synthesis of oxazolidinones: Rhodium-catalyzed C-H amination of: N -mesyloxycarbamates

N-Mesyloxycarbamates undergo intramolecular C-H amination reactions to afford oxazolidinones in good to excellent yields in the presence of rhodium(ii) carboxylate catalysts. The reaction is performed under green conditions and potassium carbonate is used, forming biodegradable potassium mesylate as a reaction by-product. This method enables the production of electron-rich, electron-deficient, aromatic and heteroaromatic oxazolidinones in good to excellent yields. Conformationally restricted cyclic secondary N-mesyloxycarbamates furnish cis-oxazolidinones in high yields and selectivity; DFT calculations are provided to account for the observed selectivity. trans-Oxazolidinones were prepared from acyclic secondary N-mesyloxycarbamates using Rh2(oct)4. The selectivity was reverted with a cytoxazone N-mesyloxycarbamate precursor using large chiral rhodium(ii) carboxylate complexes, affording the corresponding cis-oxazolidinone. This orthogonal selectivity was used to achieve the formal synthesis of (-)-cytoxazone.

Oxazolidinone derivatives: Cytoxazone-Linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells

In this study, we report the synthesis of novel oxazolidinone derivatives derived from linezolid 3 having p-methoxyphenyl group at C-4 position. In vitro evaluation for their anticancer activity toward cultured A549, DU145, HELA, and MCF7 were carried out

Synthetic microbial chemistry, XXX[≠]. - Synthesis of (-)-cytoxazone, a novel cytokine modulator isolated from Streptomyces sp.

Cytoxazone [(4R,5R]-(-)-5-hydroxymethyl-4-(4-methoxyphenyl)-2- oxazolidinone, 1], a new immunosuppressant, was synthesized by starting from p-methoxycinnamyl alcohol (2) employing the Sharpless asymmetric dihydroxylation as the key reaction in 26percent o