254763-20-7Relevant academic research and scientific papers
Efficient tin hydride-mediated radical cyclisation of secondary amides leading to substituted pyrrolidinones. Part 2. Application to the synthesis of aromatic kainic acid analogues
Bryans, Justin S.,Large, Jonathan M.,Parsons, Andrew F.
, p. 2905 - 2910 (1999)
An enantioselective synthesis of phenyl allokainoid, starting from D-serine, is reported. Tin-mediated cyclisation of a secondary amide was used in the key step to produce a trisubstituted pyrrolidinone in excellent yield (ca. 80%). The predominant format
