254878-55-2Relevant academic research and scientific papers
Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety
Van Overmeire,Boldin,Venkataraman,Zisling,De Jonghe,Van Calenbergh,De Keukeleire,Futerman,Herdewijn
, p. 4189 - 4199 (2007/10/03)
The biological activity of synthetic ceramide analogues, having modified sphingoid and N-acyl chains, as well as fluorine substituents in the allylic position, was investigated in hippocampal neurons. Their influence on axonal growth was compared to that
Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues
De Jonghe, Steven,Van Overmeire, Ilse,Gunst, Johan,De Bruyn, Andre,Hendrix, Chris,Van Calenbergh, Serge,Busson, Roger,De Keukeleire, Denis,Philippe, Jan,Herdewijn, Piet
, p. 3159 - 3164 (2007/10/03)
Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.
