254972-49-1Relevant academic research and scientific papers
A Gentler Touch: Synthesis of Modern Ruthenium Olefin Metathesis Catalysts Sustained by Mechanical Force
Mukherjee, Nirmalya,Marczyk, Anna,Szczepaniak, Grzegorz,Sytniczuk, Adrian,Kajetanowicz, Anna,Grela, Karol
, p. 5362 - 5369 (2019/11/11)
Mechanochemical synthesis of nine contemporary ruthenium catalysts used for olefin metathesis is described, being the first reported example of formation of Ru carbene organometallic complexes in solid state. Three key organometallic transformations commonly used in the synthesis of the second and third generations of Ru catalysts in solution—phosphine ligand (PCy3) exchange with in situ formed N-heterocyclic carbene (NHC) ligand, PCy3 to pyridine ligand replacement, and benzylidene ligands interchange—were proved to work under mechanochemical conditions, affording the targets in high purity. Mechanochemical approach not only requires less amounts of organic solvent (null for synthesis, only for purification) and is scalable, but also allows for transformations that were reported impossible in the solution phase.
Preparation of epothilone derivatives
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Page/Page column 6, (2010/11/24)
The invention comprises a novel process for the preparation of an epothilone derivative of formula I: wherein R1 and R2 independently from each other represent hydrogen or protecting groups and R3 is methyl or trifluoromet
