254974-59-9

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 962-39-0 L-Phenylalanine benzyl ester 

Downstream Products

• 128684-62-8 (S)-2-{[((R)-1-{(S)-5-Benzyloxycarbonylamino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-3-phenyl-propionic acid benzyl ester 
• 128684-61-7 (S)-2-[({(S)-5-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-5-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-methyl)-amino]-3-phenyl-propionic acid benzyl ester 
• 128684-25-3 (S)-2-{[((R)-1-{(S)-5-Amino-1-[(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-amino}-3-phenyl-propionic acid 
• 128684-18-4 (3S,8R,11S)-3,8-Dibenzyl-2,6,9-trioxo-1,4,7,10-tetraaza-cyclopentadecane-11-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide 
• 128684-17-3 (5S,8R,11S)-5,8-Dibenzyl-2,6,9-trioxo-1,4,7,10-tetraaza-cyclopentadecane-11-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide 
• 128684-56-0 (S)-2-(Carboxymethyl-amino)-3-phenyl-propionic acid benzyl ester; hydrochloride 

Relevant academic research and scientific papers

CYCLIC PEPTIDES AS C5 A RECEPTOR ANTAGONISTS

The invention relates to cyclic peptide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to cyclic peptide C5a receptor antagonists of formula (Ia)or formula (Ib), or pharmaceutically acceptable salts thereof,wherein R1a, R1b, R2, R3 and R4 areas defined in the description. C5a receptor antagonists are potentially useful in the treatment of a wide range of 1 disorders,including inflammatory disorders and immune disorders.

Inhibitors of Human Renin. Cyclic Peptide Analogues Containing a D-Phe-Lys-D-Trp Sequence

Cyclic peptides containing a D-phenylalanine and a D-tryptophan residue have been synthesized and tested as inhibitors of human renin.Most of these are tripeptide derivatives of the type or in which the individual side-chain methylene