254993-39-0

Basic information

• Product Name: 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-5-(methylthio)-2-oxo-N-phenyl-
• CAS NO: 254993-39-0
• Molecular Formula: C19H18N2O3S
• Molecular Weight: 354.43
• Mol File: 254993-39-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-5-(methylthio)-2-oxo-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-5-(methylthio)-2-oxo-N-phenyl-(254993-39-0)
• EPA Substance Registry System: 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-5-(methylthio)-2-oxo-N-phenyl-(254993-39-0)

Safety Data

• Hazardous Substances Data: 254993-39-0(Hazardous Substances Data)

Upstream product

• 138249-39-5 2-thio-6-fluorobenzonitrile 
• 675575-42-5 2-methylamino-6-thiomethylbenzonitrile 
• 675575-43-6 ethyl 4-amino-1,2-dihydro-1-methyl-5-methylthio-2-oxo-3-quinolinecarboxylate 
• 119584-71-3 2-fluoro-6-(methylthio)benzonitrile 
• 1897-52-5 2,6 difluorobenzonitrile 
• 100-61-8 N-methylaniline 
• 254993-47-0 ethyl 1,2-dihydro-4-hydroxy-1-methyl-5-methylthio-2-oxo-3-quinolinecarboxylate 

Relevant articles and documents

Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure-Activity Relationship

Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The compounds were tested in mice for their inhibitory effects on disease development in the acute experimental autoimmune encephalomyelitis model and selected compounds in the beagle dog for induction of proinflammatory reaction. Structure-activity relationships are discussed. Compound 8c, laquinimod, showed improved potency and superior toxicological profile compared to the lead compound roquinimex (1b, Linomide) and was selected for clinical studies (currently in phase II).