255042-04-7

Basic information

• Product Name: N-(2-Methoxyethyl)-3-phenyl-1-propanamine
• Synonyms: N-(2-Methoxyethyl)-3-phenyl-1-propanamine
• CAS NO: 255042-04-7
• Molecular Formula: C₁₂H₁₉NO
• Molecular Weight: 193.28536
• Mol File: 255042-04-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-Methoxyethyl)-3-phenyl-1-propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methoxyethyl)-3-phenyl-1-propanamine(255042-04-7)
• EPA Substance Registry System: N-(2-Methoxyethyl)-3-phenyl-1-propanamine(255042-04-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 255042-04-7(Hazardous Substances Data)

Upstream product

• 637-59-2 1-Bromo-3-phenylpropane 
• 109-85-3 2-methoxyethylamine 

Relevant articles and documents

Cesium effect: High chemoselectivity in direct N-alkylation of amines

A novel method for the mono-N-alkylation of primary amines, diamines, and polyamines was developed using cesium bases in order to prepare secondary amines efficiently. A cesium base not only promoted alkylation of primary amines but also suppressed overalkylations of the produced secondary amines. Various amines, alkyl bromides, and alkyl sulfonates were examined, and the results demonstrated this methodology was highly chemoselective to favor mono-N-alkylation over dialkylation. In particular, use of either sterically demanding substrates or amino acid derivatives afforded the secondary amines exclusively, offering wide applications in peptidomimetic syntheses.