255065-89-5Relevant academic research and scientific papers
Cardiovascular effects of novel imidazoline congeners
Shukla,Bhalla,Misra,Mukerjee,Saxsena,Sinha,Shanker
, p. 229 - 232 (2007/10/03)
2-Aryl-4,5-bis(diphenyl)-1-(N-acetyl hydrazide)-1,3-imidazoline (IIb1- 4) was prepared by the reaction of ethyl chloro acetate and hydrazine hydrate with 2-Aryl-4,5-bis (diphenyl) - 1H - imidazoline (I a1-4), which on further substitution with aryl/heterocyclyl aldheyde gave 2-Aryl-4,5-his (diphenyl)- 1-(4-substituted hydrazone) -1,3 - imidazoline (III Ca-1). This was again cyclised to oxadiazole in the presence of ferric chloride and glacial acetic acid yielded 2-Aryl-4,5-bis(diphenyl)-1-(2-substituted-1,3,4-oxadizole)-1,3- imidazoline (IV da-i). These compounds were screened for hypotensive activity and an attempt were made to get the site of action of these compounds.
