25507-04-4

Basic information

• Product Name: Clindamycin palmitate hydrochloride
• Synonyms: clindamycin2’-palmitatehydrochloride;Clindmycin;Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-hexadecanoatemonohydrochloride;Clindamycin palmitate hydrochloride;Clindamycin Hydrochloride Palmitate;Clindamycin Palmitate Hydrochloride (500 mg);Clindamycin Palmitate Hydrochloride (500 mg)G0D334586ug/mg(an);ClindaMycin PalMitate HCl USP
• CAS NO: 25507-04-4
• Molecular Formula: C₃₄H₆₃ClN₂O₆S*ClH
• Molecular Weight: 699.85
• EINECS: 1312995-182-4
• Product Categories: PHENYPASTEBAMIN;Inhibitors
• Mol File: 25507-04-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 141-143°C
• Boiling Point: 767.4 °C at 760 mmHg
• Flash Point: 417.9 °C
• Appearance: /
• Vapor Pressure: 3.44E-27mmHg at 25°C
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Clindamycin palmitate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Clindamycin palmitate hydrochloride(25507-04-4)
• EPA Substance Registry System: Clindamycin palmitate hydrochloride(25507-04-4)

Safety Data

• Hazardous Substances Data: 25507-04-4(Hazardous Substances Data)

Usage

Description

Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin . It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 25507-04-4 differently. You can refer to the following data:
1. Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.
2. antibacterial (tuberculostatic)

Brand name

Cleocin (Pharmacia & Upjohn).

General Description

Clindamycin palmitate hydrochloride (Cleocin Pediatric) isthe hydrochloride salt of the palmitic acid ester ofcleomycin. The ester bond is to the 2-hydroxyl group of thelincosamine sugar. The ester serves as a tasteless prodrugform of the antibiotic, which hydrolyzes to clindamycin inthe plasma. The salt form confers water solubility to theester, which is available as granules for reconstitution intoan oral solution for pediatric use. Although absorption of thepalmitate is slower than that of the free base, there is littledifference in overall bioavailability of the two preparations.Reconstituted solutions of the palmitate hydrochloride arestable for 2 weeks at room temperature. Such solutionsshould not be refrigerated because thickening occurs thatmakes the preparation difficult to pour.

InChI:InChI=1/C34H63ClN2O6S.ClH/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-21-27(38)42-32-30(40)29(39)31(43-34(32)44-5)28(24(3)35)36-33(41)26-22-25(20-7-2)23-37(26)4;/h24-26,28-32,34,39-40H,6-23H2,1-5H3,(H,36,41);1H/t24-,25+,26-,28+,29+,30-,31+,32+,34+;/m0./s1