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Z-Lys(Z)-OPfp, also known as N-benzyloxycarbonyl-L-lysine(N-benzyloxycarbonyl)-O-(2,4,6-trichlorophenyl)-fluorophosphate, is a synthetic chemical compound that serves as a potent irreversible inhibitor of serine proteases, a class of enzymes that play a crucial role in various biological processes. The compound is characterized by its ability to covalently bind to the active site of serine proteases, thereby inhibiting their catalytic activity. Z-Lys(Z)-OPfp is often used in biochemical research to study the function and regulation of these enzymes, as well as in the development of potential therapeutic agents targeting serine protease-mediated diseases. Its structure features a lysine residue with two benzyloxycarbonyl (Z) protecting groups, and a fluorophosphate group that mimics the transition state of the enzyme's catalytic mechanism, making it a highly effective and specific inhibitor.

25529-27-5

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25529-27-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 25529-27-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,2 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 25529-27:
(7*2)+(6*5)+(5*5)+(4*2)+(3*9)+(2*2)+(1*7)=115
115 % 10 = 5
So 25529-27-5 is a valid CAS Registry Number.

25529-27-5Relevant academic research and scientific papers

Immobilized hydrogels for screening of molecular interactions

Dominguez, Melissa M.,Wathier, Michel,Grinstaff, Mark W.,Schaus, Scott E.

, p. 1064 - 1066 (2007)

Spatially arrayed, high-density microarrays enable the rapid assessment of biological recognition events, and this information is of widespread interest for those working in basic research laboratories as well as in the clinic. Today, one can find DNA, pr

LOW-SWELLING HYDROGEL SEALANTS FOR WOUND REPAIR

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Page/Page column 256, (2010/11/25)

One aspect of the present invention relates to a sealant comprising dendrimeric macromolecules that form a hydrogel. In certain instances, the sealants of the invention comprise a hydrogel that swells less than about 400 wt% upon hydration. In certain instances, the sealants of the present invention further comprise a pharmaceutical agent, such as an antibiotic, antimicrobial agent, or antiinflammatory agent. The sealants of the present invention may be used to treat a wound on a patient that is topical or in vivo. In addition, the sealants of the present invention can act as a barrier to bacteria and other organisms. Another aspect of the present invention relates to a method of sealing a wound on a patient comprising the steps of applying an effective amount of a dendrimeric compound to a wound on a patient and treating the dendrimeric compound with a polymerization agent. Another aspect of the present invention relates to a method of sealing a wound on a patient comprising the steps of treating a dendrimeric compound with a polymerization agent to form a repair agent, and applying the repair agent to a wound on a patient. Another aspect of the present invention relates to a kit for sealing a wound comprising a polymerizable dendrimeric compound that forms a hydrogel and a system for delivering the polymerizable dendrimeric compound to a wound on a patient.

DENTRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES IN ORTHOPEDIC APPLICATIONS

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Page/Page column 269-270, (2010/10/20)

The present invention provides compositions, kits, and methods for repairing cartilaginous tissue. Certain methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine, cysteine, isocysteine residue or other nucleophilic group attached to their peripheries. Addition of a compound containing two or more electrophilic groups, such as aldehydes, activated esters, or acrylates, to the lysine-capped, cysteine-capped, or isocysteine-capped dendrimers produces a polymeric compound that can repair a cartilage defect.

DENDRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES AS OPHTHALMIC SEALANTS AND LENSES

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Page/Page column 315-316, (2010/10/20)

The present invention provides compositions and methods for sealing a wound and preparing a lens. The methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine-, cysteine-, isocysteine-residue or other nucleophilic group attached to the periphery of the dendrimer: Addition of a compound containing two or more electrophilic groups such as aldehydes, activated esters, or acrylates to the lysine-, cysteine-, or isocysteine-capped dendrimers produces a polymeric compound that can form a seal or a lens. Another aspect of the invention relates to a method of treating disease using the pharmaceutical compositions of the invention. Other aspects of the invention relate to kits for sealing a wound or preparing a lens, delivery devices, and methods for controlling the polymerization of a hydrogel system.

Dendritic macromers as in situ polymerizing biomaterials for securing cataract incisions

Wathier, Michel,Jung, Pil J.,Carnahan, Michael A.,Kim, Terry,Grinstaff, Mark W.

, p. 12744 - 12745 (2007/10/03)

Dendritic macromers are attractive macromolecules for hydrogel formation since high cross-linking densities at low polymer concentration can be obtained, varied physical properties can be observed based on the macromer structure, and low viscous aqueous s

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