2553-10-8

Usage

Uses

Used in Personal Care Industry:
4-Hydroxyphenyl 2-hydroxybenzoate is used as a preservative for its antimicrobial properties in personal care products such as lotions, creams, and sunscreen. It helps maintain product safety and extend shelf life by preventing the growth of bacteria, mold, and yeast.
However, there is an ongoing debate about the safety and regulatory approval of 4-Hydroxyphenyl 2-hydroxybenzoate due to concerns regarding its potential to disrupt hormonal balance and cause skin irritation.

Upstream product

• 123-31-9 hydroquinone 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 118-55-8 phenyl Salicylate 

Relevant academic research and scientific papers

An Abnormal Thermal Condensation of Hydroquinone with Ethyl Salicylate

Thermal condensation of hydroquinone with ethyl salicylate in refluxing diphenyl ether affords 1-hydroxyxanthone (I), 1,4-disalicyloxyhydroquinone (IIa), 4'-hyroxyphenyl salicylate (III), 1-hydroxy-4-salicyloxyxanthone (IVa), 1,4-dihydroxyxanthone (V) and 2-hydroxyxanthone (VI).The structures of these comnpounds have been confirmed by PMR and mass spectral data.

Studies in Synthesis of Xanthone Derivatives: Part III+ - A New One-step Synthesis of Xanthones

Ethyl salicylate condenses with different phenols in refluxing diphenyl ether to give various xanthones in good yields.In the case of resorcinol, hydroquinone, catechol and 3,4-xylenol corresponding phenyl salicylate derivatives are also obtained.Condensation with hydroxycoumarins affords pyranoxanthones, which can not be prepared by the Pechmann condensation of hydroxyxanthones.The structures of the intermediates and final products are established by spectral data (IR, PMR and 13C NMR).