25533-74-8

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 25373-34-6 2-(4-nitrophenyl)-2,3-dihydrobenzothiazole 
• 1441678-32-5 C₁₃H₉N₂O₂S^(1-)*C₂H₃O₂^(1-)*Hg⁽²⁺⁾ 
• 128921-77-7 5-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-3-(2-mercapto-phenyl)-2-(4-nitro-phenyl)-thiazolidin-4-one 
• 128921-81-3 1-(4-Nitro-phenyl)-benzo[d]thiazolo[4,3-b]thiazole 
• 128921-71-1 3-(2-Mercapto-phenyl)-2-(4-nitro-phenyl)-thiazolidin-4-one 
• 22868-34-4 2-(4-nitrophenyl)benzothiazole 

Relevant academic research and scientific papers

Antioxidant activity of thio-schiff bases

This study evaluated and compares the antioxidant activity of six resveratrol analogues. The analogues 4'- Hydroxyphenyl-benzo[d]thiazole (A), p-(N,N-dimethyl)aminobenzylidene-2-aminothiophenol (B) and p-Nitrobenzylidene- 2-aminothiophenol (C) were synthe

In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues

Resveratrol is a natural polyphenol found mainly on red grapes and in red wine, pointed as an important anti-inflammatory/immunomodulatory molecule. However, its bioavailability problems have limited its use encouraging the search for new alternatives agents. Thus, in this study, we synthetize 12 resveratrol analogues (6 imines, 1 thioimine and 5 hydrazones) and investigated its cytotoxicity, antioxidant activity and in vitro anti-inflammatory/immunomodulatory properties. The most promising compounds were also evaluated in vivo. The results showed that imines presented less cytotoxicity, were more effective than resveratrol on DPPH scavenger and exhibited an anti-inflammatory profile. Among them, the imines with a radical in the para position, on the ring B, not engaged in an intramolecular hydrogen-interaction, showed more prominent anti-inflammatory activity modulating, in vivo, the edema formation, the inflammatory infiltration and cytokine levels. An immunomodulatory activity also was observed in these molecules. Thus, our results suggest that imines with these characteristics presents potential to control inflammatory disorders.

Metallation of some new imines and evaluation of their antimicrobial and anticancer activity

Metallation of new imines 2-(4-(Dimethylamino)benzylidene- amino)benzenethiol (1) and 2-(4-nitrobenzylideneamino)-benz- enethiol(5) with Hg(II), Ni(II) acetate, and palladium chloride afforded metallated products (2), (3), and (4) in the form of monomercu

An efficient and environmental benign synthesis of 2-benzimidazoles and 2-benzothiazoles using CeCl3-NaI as catalyst

A one-pot condensation of an aldehyde with 1,2-phenylenediamine or 2-aminothiophenol in dimethyl carbonate at 100°C under O2 in the presence of catalytic amounts of CeCl3-NaI gave an imine intermediate, which cyclised and dehydrogenated to give 2-arylbenzimidazoles or 2-arylbenzothiazoles in good yields.