25536-08-7Relevant academic research and scientific papers
α-Arylation of Carbonyl Compounds through Oxidative C?C Bond Activation
Li, Jing,Bauer, Adriano,Di Mauro, Giovanni,Maulide, Nuno
, p. 9816 - 9819 (2019/06/25)
A synthetically useful approach for the direct α-arylation of carbonyl compounds through a novel oxidative C?C bond activation is reported. This mechanistically unusual process relies on a 1,2-aryl shift and results in all-carbon quaternary centers. The transformation displays broad functional-group tolerance and can in principle also be applied as an asymmetric variant.
Synthesis of pyrazolines by a site isolated resin-bound reagents methodology
Gembus, Vincent,Bonnet, Jean-Jacquesrouen,Janin, Franoisrouen,Bohn, Pierre,Levacher, Vincent,Briere, Jean-Franois
experimental part, p. 3287 - 3293 (2010/08/21)
The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities. The Royal Society of Chemistry 2010.
