25552-07-2Relevant academic research and scientific papers
Thiourea-catalyzed enantioselective addition of indoles to pyrones: Alkaloid cores with quaternary carbons
Yeung, Charles S.,Ziegler, Robert E.,Porco, John A.,Jacobsen, Eric N.
, p. 13614 - 13617 (2014)
We report the development of a catalytic method for the enantioselective addition of indoles to pyrone-derived electrophiles. Arylpyrrolidino-derived thioureas catalyze the addition with high stereoselectivity in the presence of catalytic quantities of an achiral Bronsted acid. The indole-pyrone adducts feature a quaternary stereocenter and represent an unusual class of indolines bearing structural resemblance to the hybrid natural product pleiocarpamine.
