25564-59-4Relevant academic research and scientific papers
A new type of complex reagent, R4Pb / TiCl4
Yamamoto, Yoshinori,Yamada, Jun-Ichi,Asano, Tetsuya
, p. 5587 - 5596 (2007/10/02)
Tetraalkllleads (R4Pb) reacted quite smoothly with aldehydes R'CHO in the presence of TiCl4 to produce the corresponding alcohols (RCHOHR′) in high to good yields. The reagent system, R4Pb/ TiCl4, exhibited high chemoselectivity; only aldehydes underwent the alkylation in the presence of ketones. Further, the new reagent exhibited high 1,2- and 1,3-asymmetric induction. The transfer order of alkyl groups in the reaction of aldehydes with mixed tetraalkylleads/TiCl4 was determined; Me>Et.i-Pr?n-Bu.
