255841-23-7Relevant academic research and scientific papers
7-Azabicycloheptane Carboxylic Acid: A Proline Replacement in a Boroarginine Thrombin Inhibitor
Han, Wei,Pelletier, Jeffrey C.,Mersinger, Lawrence J.,Kettner, Charles A.,Hodge, Nicholas C.
, p. 1875 - 1877 (2008/02/11)
(Matrix Presented) The synthesis of thrombin inhibitor 3, which incorporates conformationally constrained 7-azabicycloheptane carboxylic acid (1) as a proline replacement, is described. The inhibition constant (Ki(thrombin) = 2.9 nM) indicates
