255851-82-2Relevant academic research and scientific papers
An Octakis-intercalating molecule
Murr, Meredith M.,Harting, Matthew T.,Guelev, Vladimir,Ren, Jinsong,Chaires, Jonathan B.,Iverson, Brent L.
, p. 1141 - 1148 (2007/10/03)
Herein we report the synthesis and characterization of a polyintercalator with eight potential intercalating 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) units linked in a head-to-tail arrangement via a peptide linker. UV spectroscopy and viscometry measurements indicated the molecule binds to double-stranded DNA with all eight NDI units intercalated simultaneously. Competition dialysis and DNAse 1 footprinting studies revealed a preference for GC-rich regions of DNA, and circular dichroism studies revealed significant distortion of B-form DNA upon binding. Our so-called 'octamer' represents, to the best of our knowledge, the first intercalator that binds as an octakis-intercalator, capable of spanning at least 16 base pairs of DNA.
Synthesis of a C-linked antifreeze glycoprotein (AFGP) mimic: Probes for investigating the mechanism of action
Ben, Robert N.,Eniade, Adewale A.,Hauer, Lisa
, p. 1759 - 1762 (2008/02/11)
(formula presented) A general convergent synthesis has been developed to afford a low molecular weight C-linked antifreeze glycoprotein (AFGP) mimic (9). Structural mimics of AFGPs have tremendous potential as probes to better understand how native AFGPs
