2560-31-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-FLUORO-PHENYL)-4-PIPERAZIN-1-YL-BUTAN-1-ONE is used as a research chemical for the development of novel psychoactive substances. Its potential stimulant or hallucinogenic effects make it a candidate for further investigation into its pharmacological properties and possible applications in the treatment of various psychiatric disorders.
Used in Research and Development:
In the field of scientific research, 1-(4-FLUORO-PHENYL)-4-PIPERAZIN-1-YL-BUTAN-1-ONE serves as a valuable compound for studying the mechanisms of action of psychoactive substances. Its structural features and potential effects on the central nervous system provide researchers with insights into the design and synthesis of new drugs with improved safety and efficacy profiles.
Used in Forensic Toxicology:
1-(4-FLUORO-PHENYL)-4-PIPERAZIN-1-YL-BUTAN-1-ONE may also be utilized in forensic toxicology as a reference compound for the identification and analysis of emerging designer drugs. Its unique chemical structure aids in the development of analytical methods and techniques for detecting and quantifying similar substances in biological samples.

Upstream product

• 3308-94-9 4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 212831-73-7 1-(4-fluorophenyl)-4-(4-triphenylmethyl-1-piperazinyl)-1-butanone 
• 55846-41-8 1-(3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-propyl)piperazine 
• 110-85-0 piperazine 

Downstream Products

• 603-35-0 triphenylphosphine 
• 133496-69-2 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one 
• 133496-57-8 3-{4-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one 
• 212831-76-0 1-[(4-fluorophenyl)-4-oxobutyl]-4-[(2-hydroxy-3-phenylamino)propyl]piperazine 
• 252253-35-3 N-(5-Dimethylaminomethyleneamino-2-pyrimidyl)-N'-[4-(p-fluorophenyl)-4-oxobutyl]piperazine 
• 133496-63-6 3-(4-Fluoro-benzyl)-4-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-yl}-butyric acid methyl ester 
• 133496-53-4 3-Benzyl-4-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-yl}-butyric acid methyl ester 
• 88848-15-1 7-fluoro-2-isopropyldibenzothiepin 
• 113305-80-9 1-(4-fluorophenyl)-4-(4-(7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin-11-yl)piperazine-1-yl)butan-1-one 
• 77795-83-6 4-[4-(8-Chloro-3,7-difluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one 
• 90061-59-9 2-chloro-11-<4-(3-<4-fluorobenzoyl>propyl)piperazino>-10,11-dihydrodibenzothiepin 

Relevant academic research and scientific papers

Identification of metabolites of azaperone in horse urine

Two metabolites of the tranquilizer azaperone were extracted from alkalinized horse urine after treatment with β-glucuronidase/sulfatase from limpets (Patella vulgata). The metabolites were identified by a combination of independent chemical synthesis and GC/MS and 1H NMR analysis. The metabolites were identified as 1-(fluorophenyl)-4-[4-(5-hydroxy-2-pyridinyl)- 1-piperazinyl]-1-butanol, designated as 5'-hydroxyazaperol, and 1- (fluorophenyl)-4-[4-(5-hydroxy-2-pyridinyl)-1-piperazinyl]-1-butanone, designated as 5'-hydroxyazaperone. A TLC screening test was developed for detecting both metabolites in basic extracts of horse urine treated with β- glucuronidase/sulfatase. The screening test was used to detect azaperone metabolites in extracts of horse urine collected for 24 h alter intravenous administration of azaperone. The administration of azaperone to horses was confirmed by GC/MS identification of 5'-hydroxyazaperone and 5'- hydroxyazaperol from basic extracts of horse urine treated with β- glucuronidase/sulfatase. The extracted metabolites were treated with bis(trimethylsilyl)acetamide to produce trimethylsilyl (TMS) ether derivatives, and mass spectra and retention times were compared to those of the synthesized metabolites treated in the same manner.

Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system

A new series of diphenyl piperazine derivatives containing the phenyl substituted aminopropanol moiety, which were modified at sites between the diphenyl and piperazine moieties, was prepared and evaluated for dopamine transporter binding affinity with [

Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone

Starting from β-benzoylpropionic acid we synthesized 3-(aminomethyl)tetralones in which the amino substituent was 4-(N-piperazinyl)-p-fluorobutyrophenone (14), 4-benzoylpiperidine (15), 4-hydroxy-4-phenylpiperidine (16) or 4-(o-methoxyphenyl)piperazine (1