256218-65-2

Upstream product

• 256218-56-1 acetic acid 3,3-dichloro-4-(chloro-phenyl-methyl)-tetrahydro-furan-2-yl ester 
• 404580-70-7 [(2,2,2-trichloroethoxy)prop-1-enyl]benzene 
• 4392-24-9 Cinnamyl bromide 
• 954114-78-4 3,3-dichloro-4-[chloro(phenyl)methyl]tetrahydrofuran 

Relevant academic research and scientific papers

Unexpected aromatization of 2-acetoxy-3, 3-dichloro-4-(α-chloroalkyl) tetrahydrofurans to 3-alkyl-4-chlorofurans with NaI/DMF

An unexpected aromatization of 2-acetoxy-3,3-dichloro-4-(α- chloroalkyl)tetrahydrofurans to 3-alkyl-4-chlorofurans occurs on heating with sodium iodide in dimethylformamide (DMF) at 120°C. Copyright Taylor & Francis Group, LLC.

Synthesis of 3-substituted and 2,3-disubstituted 4-chlorofurans

A simple method for the synthesis of 3-substituted and 2,3-disubstituted 4-chlorofurans is described which involves CuCl/bipy-catalysed regioselective cyclisation of 1-acetoxy-2,2,2-trichloroethyl allyl ethers followed successively by dechloroacetoxylation with Zn dust and tandem dehydrohalogenation-aromatisation with Bu(t)OK/18-crown-6.