25622-75-7

Basic information

• Product Name: 1-pentafluorophenyl-2-methylpropanol-1
• Synonyms: 1-pentafluorophenyl-2-methylpropanol-1
• CAS NO: 25622-75-7
• Molecular Weight: 240.173
• Mol File: 25622-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-pentafluorophenyl-2-methylpropanol-1(CAS DataBase Reference)
• NIST Chemistry Reference: 1-pentafluorophenyl-2-methylpropanol-1(25622-75-7)
• EPA Substance Registry System: 1-pentafluorophenyl-2-methylpropanol-1(25622-75-7)

Safety Data

• Hazardous Substances Data: 25622-75-7(Hazardous Substances Data)

Upstream product

• 1206-46-8 trimethyl(pentafluorophenyl)silane 
• 70533-09-4 1-pentafluorophenyl-1-trimethylsiloxy-2-methylpropane 

Relevant articles and documents

N-heterocyclic carbene-catalysed pentafluorophenylation of aldehydes

N-heterocyclic carbenes have been utilized as highly efficient organocatalysts to catalyse multifluorophenylation of aldehydes with pentafluorophenyltrimethylsilane or bis(trimethylsilyl)tetrafluorobenzene to afford the corresponding fluorinated adducts in 49-99% yields.

REACTIONS OF PENTAFLUOROPHENYLTRIMETHYLSILANE AND CYANOMETHYLTRIMETHYLSILANE WITH CARBONYL COMPOUNDS CATALYZED BY CYANIDE ANIONS

Treatment of pentafluorophenyltrimethylsilane (I) and cyanomethyltrimethylsilane (II) with enolizable ketones in the presence of a catalytic amount of potassium cyanide-18-crown-6 complex gave the corresponding trimethylsilyl enol ethers.The same dehydrogenative silylation of acetylacetone and benzoylacetone with silane I was extended to the preparation of 2,4-bis(trimethylsiloxy)-1,3-pentadiene and 1-phenyl-1,3-bis(trimethylsiloxy)-1,3-butadiene, respectively.The dehydrogenative silylation of acetylacetone and benzoylacetone with dimethylbis(pentafluorophenyl)silane u nder the same conditions affords novel heterocycles 5-methylene-2,6-dioxa-1-silacyclohex-3-enes.In the reaction studied the silylating ability of the silanes increases in the order Me3SiCN ca.Me2Si(CN)2 Me3SiCH2CN Me3SiC6F5 ca.Me2Si(C6F5)2.On the other hand, potassium cyanide-18-crown-6 complex catalyzed the addition of silane I or II to a carbonyl group of non-enolizable compounds such as benzaldehyde, crotonaldehyde, and methyl(triethylgermyl)ketene.