256339-21-6

Basic information

• Product Name: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylthio)phenyl]furan-2(5H)-one
• Synonyms: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylthio)phenyl]furan-2(5H)-one
• CAS NO: 256339-21-6
• Molecular Weight: 304.41
• Mol File: 256339-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylthio)phenyl]furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylthio)phenyl]furan-2(5H)-one(256339-21-6)
• EPA Substance Registry System: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylthio)phenyl]furan-2(5H)-one(256339-21-6)

Safety Data

• Hazardous Substances Data: 256339-21-6(Hazardous Substances Data)

Upstream product

• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 189954-96-9 3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one 

Relevant articles and documents

Palladium-Catalyzed Thiomethylation via a Three-Component Cross-Coupling Strategy

In this report, the combination of masked inorganic sulfur and dimethyl carbonate was designed to achieve thiomethylated cross coupling of aryl chlorides. Remarkably, this powerful strategy realized thiomethylation of nucleosides bearing unprotected ribose, chloride-containing pharmaceuticals with late-stage coupling, and herbicides possessing multiple heteroatoms and steric hindrance. Moreover, this protocol is practically amenable to multigram-scale synthesis with a lower catalysis loading and a higher yield.