256341-83-0Relevant articles and documents
Total synthesis of everninomicin 13,384-1 - Part 2: Synthesis of the FGHA2 fragment
Nicolaou,Mitchell, Helen J.,Fylaktakidou, Konstantina C.,Rodriguez, Rosa Maria,Suzuki, Hideo
, p. 3116 - 3148 (2007/10/03)
The stereoselective synthesis of everninomicin's 13,384-1 (1) FGHA2 fragment (2) in a suitable form for incorporation into the final target (1) is described. The construction of the FG 1,1′-disaccharide linkage relied on a new method based on tin-acetal chemistry, while for the GH orthoester bridge, a number of approaches were explored. Final success for the latter construction came when a novel 1,2-phenylseleno migration reaction was applied to couple rings G and H, followed by ketene acetal and orthoester formation.
