256345-59-2

Upstream product

• 256345-55-8 5-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-3-trifluoromethanesulfonyloxy-indazole-1-carboxylic acid tert-butyl ester 
• 256345-53-6 (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-hydroxy-1H-indazol-5-ylmethyl)-2,2-dimethyl-7-(3-nitro-benzyl)-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one 
• 256345-52-5 5-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-2-fluoro-benzoic acid methyl ester 
• 2967-93-3 2-fluoro-5-methyl benzoic acid methyl ester 
• 709-45-5 2-fluoro-5-bromomethyl benzoic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 256345-54-7 5-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-3-hydroxy-indazole-1-carboxylic acid tert-butyl ester 
• 321-12-0 2-fluoro-5-methyl-benzoic acid 
• 64113-84-4 2-fluoro-5-methylbenzonitrile 

Downstream Products

• 256345-69-4 5-[(3aS,4R,8R,8aS)-7-(3-Amino-benzyl)-4,8-dibenzyl-2,2-dimethyl-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-3-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazol-3-yl]-indazole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2' substituents

The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.