256366-58-2Relevant academic research and scientific papers
Enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinoyl)imines catalyzed by β-aminoalcohols with the prolinol skeleton
Almansa, Raquel,Guijarro, David,Yus, Miguel
, p. 2828 - 2840 (2008/03/28)
Several β-aminoalcohols with the prolinol framework are shown to be very efficient catalysts for the enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinoyl)imines. The use of 0.5 equiv of the catalyst leads to the expected addition products in good yields and with ee up to 94% in a reaction time of only 4 h at room temperature. This ee is the highest value reported so far using 0.5 equiv of an aminoalcohol as a promoter. High enantioselectivities are obtained in the addition of dialkylzincs to both aromatic and aliphatic imines. The amount of the catalyst can be reduced to 0.25 equiv with a slight decrease in the ee. A very interesting effect of the addition rate and temperature on the enantioselectivity was also observed.
Optically active cyclic amino acid ester derivatives and processes for producing the same
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, (2008/06/13)
There are disclosed a process for producing the optically active cyclic amino acid ester derivative of the formula (I): by optical resolution method, a process for producing the same and a process for producing an optically active cyclic amino acid using the compound of the formula (I).
