256367-01-8Relevant academic research and scientific papers
Synthesis of benzimidazole derivatives as antiallergic agents with 5- lipoxygenase inhibiting action
Nakano, Hiroyuki,Inoue, Tsutomu,Kawasaki, Nobuhide,Miyataka, Hideki,Matsumoto, Hitoshi,Taguchi, Takeo,Inagaki, Naoki,Nagai, Hiroichi,Satoh, Toshio
, p. 1573 - 1578 (2007/10/03)
Syntheses were conducted of novel benzimidazole derivatives that suppress histamine release from mast cells, inhibit 5-lipoxygenase, and possess antioxidative action. Among the compounds synthesized, 1-[2-[2-(4- hydroxy-2,3,5-trimethylphenoxy)ethoxy]ethyl]-2-(4-methyl-1- homopiperazino)benzimidazole (22) potently suppressed histamine release from rat peritoneal mast cells triggered by the antigen-antibody reaction, inhibited 5-lipoxygenase in rat basophilic leukemia-1 (RBL-1) cells, and prevented the NADPH-dependent lipid peroxidation induced by Fe3+-ADP in rat liver microsomes, in addition to an antagonizing the contraction of guinea pig ileum caused by histamine.
