256373-91-8

Basic information

• Product Name: ETHYL 5-(CHLOROSULFONYL)-3-FUROATE
• Synonyms: ETHYL 5-(CHLOROSULFONYL)-3-FUROATE;5-Chlorosulphonyl-furan-3-carboxylicacidethylester;5-Chlorosulfonyl-furan-3-carboxylic acid ethyl ester
• CAS NO: 256373-91-8
• Molecular Formula: C₇H₇ClO₅S
• Molecular Weight: 238.65
• Mol File: 256373-91-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 339.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.461±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ETHYL 5-(CHLOROSULFONYL)-3-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-(CHLOROSULFONYL)-3-FUROATE(256373-91-8)
• EPA Substance Registry System: ETHYL 5-(CHLOROSULFONYL)-3-FUROATE(256373-91-8)

Safety Data

• Hazardous Substances Data: 256373-91-8(Hazardous Substances Data)

Usage

Description

ETHYL 5-(CHLOROSULFONYL)-3-FUROATE is a chemical compound that belongs to the class of sulfonates. It is a white to light yellow crystalline powder that is soluble in organic solvents and is known for its strong chlorosulfonylating properties, making it a valuable reagent in organic synthesis.

Uses

Used in Pharmaceutical Industry:
ETHYL 5-(CHLOROSULFONYL)-3-FUROATE is used as an intermediate in the synthesis of pharmaceuticals for its ability to facilitate the formation of various drug molecules.
Used in Agrochemical Industry:
ETHYL 5-(CHLOROSULFONYL)-3-FUROATE is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Dye and Pigment Production:
ETHYL 5-(CHLOROSULFONYL)-3-FUROATE is used in the production of dyes and pigments, playing a role in creating a wide range of colors for various applications.
Used in Organic Synthesis:
ETHYL 5-(CHLOROSULFONYL)-3-FUROATE is used as a reagent in organic synthesis, taking advantage of its strong chlorosulfonylating properties to aid in the creation of diverse organic compounds.
It should be noted that due to its potentially hazardous nature, ETHYL 5-(CHLOROSULFONYL)-3-FUROATE should be handled with care.

Upstream product

• 614-98-2 ethyl 3-furancarboxylate 
• 256373-92-9 ethyl 4-furoate-2-sulfonic acid 

Downstream Products

• 256373-94-1 ethyl 5-sulfamoylfuran-3-carboxylate 

Relevant articles and documents

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

This study describes the syntheses of di, tetra and hexa deuterated analogues of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome inhibitor MCC950. In di and tetra deuterated analogues, deuteriums were incorporated into the 1,2,3,5,6,7-hexahydro-s-indacene moiety, whereas in the hexa deuterated MCC950 deuteriums were incorporated into the 2-(furan-3-yl)propan-2-ol moiety. The di deuterated MCC950 analogue was synthesised from 4-amino-3,5,6,7-tetrahydro-s-indacen-1(2H)-one 5. Tetra deuterated analogues were synthesised in 10 chemical steps starting with 5-bromo-2,3-dihydro-1H-inden-1-one 9, whereas the hexa deuterated analogue was synthesised in four chemical steps starting with ethyl-3-furoate 24. All of the compounds exhibited similar activity to MCC950 (IC50 = 8 nM). These deuterated analogues are useful as internal standards in LC-MS analyses of biological samples from in vivo studies.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Sulfonamide compound and medical applications thereof

The invention discloses a compound containing a sulfonamide structure, a preparation method thereof, and medical applications of the compound, and more specifically discloses the compound with a structure represented by formula I, and a pharmaceutically acceptable salt or a prodrug or a solvate thereof. The compound is used for tumor treatment through inhibiting ATP-citrate lyase.