256419-35-9

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 256419-31-5 4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester 
• 256419-34-8 4(R)-((N-t-butoxycarbonyl)amino)-2(R)-(4-methoxybenzylamino)-5-phenyl-pentane-1,3(S)-diol 

Downstream Products

• 256419-44-0 4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one 
• 256419-45-1 (4R,5S,6R)-4-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-hydroxymethyl-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one 
• 746592-74-5 7-benzyl-6-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-(4-methoxy-benzyl)-[1,4]diazepan-2-one 
• 256419-39-3 4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one 
• 790645-95-3 (5R,6S,7R)-7-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-(4-methoxy-benzyl)-[1,4]diazepan-2-one 
• 256419-40-6 (4R,5S,6R)-4-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-hydroxymethyl-1-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one 

Relevant academic research and scientific papers

Backbone stabilized peptidomimetics containing statine-like structural elements: Diastereospecific synthesis of trisubstituted cyclic ureas and 1,4-diazepan-2-ones

2-Aminobenzyl substituted 4-amino-3-hydroxy-5-phenyl pentanoic acid (AHPPA) is the central structural element of highly active HIV-protease inhibitors. To obtain conformationally less flexible staline analogs, we stabilized AHPPA via ring formations, e.g.