256439-58-4Relevant academic research and scientific papers
Preparation of N-heterocycles by radical cyclisation of enamides mediated by manganese(III) or copper(I). A comparison of cyclisation methods
Davies, David T.,Kapur, Neha,Parsons, Andrew F.
, p. 3941 - 3949 (2007/10/03)
Reaction of enamides with manganese(III) acetate or copper(I) chloride/bipyridine has been investigated. In both cases, an initial 5-endo- trig radical cyclisation reaction took place to produce functionalised pyrrolidinones. The copper(I)-mediated cyclisations were very efficient and bicyclic dienes could be isolated in >80% yield, while the corresponding manganese(III) reactions were generally more problematic, giving related dienes in lower yield (35-52%). (C) 2000 Elsevier Science Ltd.
