256441-19-7

Upstream product

• 208454-73-3 1-{3-[6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-1,5-dioxa-benzocyclohepten-7-yloxy]-octahydro-pyrano[3,2-b]pyran-2-yl}-ethanol 
• 208454-53-9 1-{3-[6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-1,5-dioxa-benzocyclohepten-7-yloxy]-octahydro-pyrano[3,2-b]pyran-2-yl}-ethanone 
• 208454-72-2 6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-7-(2-vinyl-octahydro-pyrano[3,2-b]pyran-3-yloxy)-octahydro-1,5-dioxa-benzocycloheptene 
• 256441-21-1 (2R,3S,4aR,5aS,9R,10aR,12aS)-3-(tert-Butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-9-[(2R,3S)-3-((Z)-3-trimethylsilanyl-propenyloxy)-tetrahydro-pyran-2-ylmethyl]-decahydro-1,5,8,10-tetraoxa-benzo[b]heptalene 
• 208454-46-0 2-[(2R,3S,4aR,6S,7R,9aS)-3-(tert-Butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-7-((2R,3S,4aR,8aS)-2-vinyl-octahydro-pyrano[3,2-b]pyran-3-yloxy)-octahydro-1,5-dioxa-benzocyclohepten-6-yl]-ethanol 
• 208454-80-2 (2R,3S,4aR,5aS,9R,10aR,12aS)-9-((2R,3S)-3-Allyloxy-tetrahydro-pyran-2-ylmethyl)-3-(tert-butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1,5,8,10-tetraoxa-benzo[b]heptalene 
• 208454-47-1 (2R,3S,4aR,6S,7R,9aS)-3-(tert-Butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(2-hydroxy-ethyl)-octahydro-1,5-dioxa-benzocyclohepten-7-ol 
• 208454-48-2 ((2R,3S)-3-Allyloxy-tetrahydro-pyran-2-yl)-acetaldehyde 
• 208454-54-0 2-bromo-1-{3-[3-(tert-butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(2-hydroxy-ethyl)-octahydro-1,5-dioxa-benzocyclohepten-7-yloxy]-octahydro-pyrano[3,2-b]pyran-2-yl}-ethanone 

Downstream Products

• 208454-58-4 C₄₀H₅₄O₉Si 
• 208454-74-4 C₄₀H₅₆O₉Si 
• 256441-39-1 C₄₄H₆₄O₈S₂Si 
• 208454-57-3 C₅₆H₇₄O₉Si₂ 
• 256441-28-8 C₅₆H₇₄O₁₀Si₂ 
• 208454-56-2 C₆₃H₇₈O₁₁SSi₂ 
• 208454-61-9 C₆₈H₁₀₂O₁₄S₂Si 

Relevant academic research and scientific papers

A Convergent Synthesis of the Decacyclic Ciguatoxin Model Containing the F-M Ring Framework

A highly convergent synthesis of the decacyclic ciguatoxin model 2, which contains the F-M ring framework of the natural product, has been achieved through the assembly of pentacyclic oxonane 4 and JKLM ring fragment 5. The two key steps in the synthesis of the former compound are (i) a Lewis acid-mediated intramolecular reaction of a γ-alkoxyallylsilane with an acetal group to form an O-linked oxacycle and (ii) a SmI2-mediated intramolecular Reformatsky reaction leading to construction of the annelated oxonane ring system. Preliminary biological investigations revealed that model compound 2 did not inhibit the binding of tritium-labeled dihydrobrevetoxin B to voltage-sensitive sodium channels at micromolar concentrations.