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256443-12-6

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256443-12-6 Usage

General Description

1-(3,5-Dichloropyridin-4-ylmethyl)-6-methoxy-4-(1H-1,2,4-triazol-1-yl)phthalazine, also known as Vicoguad, is a novel chemical compound that has potential pharmacological applications. It belongs to the class of phthalazine derivatives and contains a 1,2,4-triazole ring, which is commonly found in various pharmaceutical compounds. The chemical structure of Vicoguad suggests that it may have biological activity as an inhibitor or modulator of specific enzymes or receptors in the body, making it a potential candidate for further medicinal chemistry research and drug development. The compound's unique chemical features make it of interest to scientists and researchers studying its potential therapeutic effects in various disease conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 256443-12-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,6,4,4 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 256443-12:
(8*2)+(7*5)+(6*6)+(5*4)+(4*4)+(3*3)+(2*1)+(1*2)=136
136 % 10 = 6
So 256443-12-6 is a valid CAS Registry Number.

256443-12-6Downstream Products

256443-12-6Relevant articles and documents

Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstituted derivatives

Haack, Thomas,Fattori, Raimondo,Napoletano, Mauro,Pellacini, Franco,Fronza, Giovanni,Raffaini, Giuseppina,Ganazzoli, Fabio

, p. 4425 - 4433 (2005)

This report describes the detailed conformational analysis and synthesis of a series of phthalazine phosphodiesterase-type (IV) (PDE IV) inhibitors bearing either mono- or dichloro 4-methylenepyridine at the 'down' position of the phthalazine nucleus or different heterocycles at the 'top' position 4 of the phthalazine moiety. Both the mono- and dichloro 4-methylenepyridine units linked at carbon C1 of the phthalazine nucleus show identical conformational behaviour with the substituent preferentially oriented towards the external part of the molecule and the pyridine plane almost orthogonal to that of phthalazine ring. The heterocyclic five-membered rings linked at carbon C4 of phthalazine show quite different conformational behaviour. The 1,3-thiazole ring exists in a well-defined conformation almost coplanar with respect to the phthalazine nucleus while the 1,2,4-triazole and the 1,3-diazole heterocycles show a great conformational freedom with large torsion angles. Compound 3 bearing the thiazole ring at C4 displays the major biological activity, thus suggesting that a planar and rather rigid conformation of the pentacycle should favour the PDE IV inhibition capacity of this class of compounds.

Phthalazine derivatives phosphodiesterase 4 inhibitors

-

, (2008/06/13)

The present invention provides a compound selected from the group including: 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenyl-phthalazine; 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-carboxylic acid methyl ester; benzyl-{3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-ynyl}-methyl-amine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-5-(5-morpholin-4-yl-pent-1-ynyl)-phthalazine dihydrochloride; 3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-yn-1-ol; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-morpholin-4-yl-phthalazine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-(1,2,4)triazol-1-yl-phthalazine; N→O derivatives thereof; and pharmaceutically acceptable salts thereof. The invention also provides a pharmaceutical composition which includes a therapeutically effective amount of the above compound in admixture with a suitable carrier.

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