256454-46-3

Basic information

• Product Name: 3-(4-tolyl)-3,4-dihydro-2H-benzo-1,4-oxazin-2-one
• Synonyms: 3-(4-tolyl)-3,4-dihydro-2H-benzo-1,4-oxazin-2-one
• CAS NO: 256454-46-3
• Molecular Weight: 239.274
• Mol File: 256454-46-3.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-tolyl)-3,4-dihydro-2H-benzo-1,4-oxazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-tolyl)-3,4-dihydro-2H-benzo-1,4-oxazin-2-one(256454-46-3)
• EPA Substance Registry System: 3-(4-tolyl)-3,4-dihydro-2H-benzo-1,4-oxazin-2-one(256454-46-3)

Safety Data

• Hazardous Substances Data: 256454-46-3(Hazardous Substances Data)

Upstream product

• 1255772-29-2 3-(4-methylphenyl)-2H-benzo[b][1,4]oxazin-2-one 

Relevant articles and documents

Renewable Molecular Flasks with NADH Models: Combination of Light-Driven Proton Reduction and Biomimetic Hydrogenation of Benzoxazinones

Using small molecules with defined pockets to catalyze chemical transformations resulted in attractive catalytic syntheses that echo the remarkable properties of enzymes. By modulating the active site of a nicotinamide adenine dinucleotide (NADH) model in a redox-active molecular flask, we combined biomimetic hydrogenation with in situ regeneration of the active site in a one-pot transformation using light as a clean energy source. This molecular flask facilitates the encapsulation of benzoxazinones for biomimetic hydrogenation of the substrates within the inner space of the flask using the active sites of the NADH models. The redox-active metal centers provide an active hydrogen source by light-driven proton reduction outside the pocket, allowing the in situ regeneration of the NADH models under irradiation. This new synthetic platform, which offers control over the location of the redox events, provides a regenerating system that exhibits high selectivity and efficiency and is extendable to benzoxazinone and quinoxalinone systems.

The first general, highly enantioselective lewis base organocatalyzed hydrosilylation of benzoxazinones and quinoxalinones

The first general, highly enantioselective hydrosilylation of benzoxazinones and quinoxalinones has been developed. The chiral Lewis base organocatalysis that are readily accessible from (1S,2R)-ephedrine and (1R,2S)-ephedrine promoted the title reaction to afford various chiral dihydrobenzoxazinones and dihydroquinoxalinones with good yields as well as good enantioselectivities.