25650-75-3Relevant academic research and scientific papers
BIOTRANSFORMATION OF ISOQUINOLINE ALKALOIDS WITH RAT LIVER MICROSOMES
Kametani, Tetsuji,Kanaya, Naoaki,Ohta, Yohko,Ihara, Masataka
, p. 963 - 970 (2007/10/02)
Optically active (+)-reticuline (1) was biotransformed into (-)-coreximine (2), (-)-scoulerine (3), (+)-isoboldine (4) and (-)-pallidine (5) with retention of the chirality by the incubation with rat liver microsomes.On the other hand, the racemate of reticuline formed the racemates of the above alkaloids on the some treatment.The S-adenosylmethionine was partially incorporated into the berberine bridge during the biotransformation of reticuline into the protoberberines.
