256519-11-6

Basic information

• Product Name: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
• Synonyms: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI);1H-BENZIMIDAZOLE, 2-CHLORO-4-FLUORO-;2-Chloro-4-fluoro-1H-benzo[d]imidazole;2-chloro-4-fluoro-1H-1,3-benzodiazole;2-Chloro-7-fluoro-1H-benzo[d]imidazole;2-Chloro-4-fluoro-1H-benzimidazole
• CAS NO: 256519-11-6
• Molecular Formula: C7H4ClFN2
• Molecular Weight: 170.57
• Product Categories: BENZIMIDAZOLE
• Mol File: 256519-11-6.mol

Chemical Properties

• Boiling Point: 332.888 °C at 760 mmHg
• Flash Point: 155.126 °C
• Appearance: /
• Density: 1.533 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.60±0.30(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)(256519-11-6)
• EPA Substance Registry System: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)(256519-11-6)

Safety Data

• Hazardous Substances Data: 256519-11-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) is used as an intermediate compound for the synthesis of more complex pharmaceutical compounds. Its unique structure with a chlorine and fluorine atom allows for further chemical reactions and modifications, leading to the development of new drugs with potential therapeutic applications.
Used in Pesticide Industry:
In the pesticide industry, 1H-Benzimidazole,2-chloro-4-fluoro-(9CI) is employed as a starting material for the production of various agrochemicals. Its chemical properties enable it to be incorporated into the structures of pesticides, potentially enhancing their effectiveness in controlling pests and diseases in agriculture.
Used in Industrial Applications:
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) is utilized as a chemical intermediate in various industrial processes. Its versatility in chemical reactions allows it to be a key component in the synthesis of a wide range of industrial products, such as dyes, plastics, and other specialty chemicals. 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)'s presence in these applications contributes to the development of innovative materials with improved properties and performance.

InChI:InChI=1/C7H4ClFN2/c8-7-10-5-3-1-2-4(9)6(5)11-7/h1-3H,(H,10,11)

Upstream product

• 18645-88-0 3-fluorobenzene-1,2-diamine 
• 256519-10-5 4-fluoro-1,3-dihydro-2H-1,3-benzimidazole-2-one 

Relevant articles and documents

CHEMICAL COMPOUNDS

There is provided pyrimidinyl compounds of Formula (I), wherein: R2 is or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives

Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists (2 and 3). By optimizing substituents on the benzimidazole core part of the lead compound 5a, we were able to develop a potent, orally available, and brain-penetrable Y5 selective antagonist (5k). Crown Copyright

FKBP inhibitors

Compounds of formula (I), their salts and solvates, wherein the substituents are as described herein, are FKBP inhibitors.